Dr. Sandeep Singh

• President, WAUPS – SOUTH EAST ASIA.
• International Board Member, WAUPS, South Korea.
• International Board Member, Global Implantology Summit, California, USA. 
• Fellow, WAUPS, South Korea. 
• Fellow, BADI, Bangladesh Academy of Dentistry International.
• Former Resident, AIIMS, New Delhi. 
• Director, Dental Health & Sciences, SHUATS, University, Allahabad.
• Certified Endodontic Trainer, Mallifer Institute, Dentsply Sirona, Switzerland.
• Certified Trainer for Advanced Hard & Soft Tissue Regeneration Techniques, Urban Regeneration Institute, Budapest, Hungary. 
• Certified Trainer for Advanced Hard & Soft Tissue Regeneration Techniques, Department of Dental Studies, University of Bern, Switzerland. 
• Director, Sahaj Dental Care & Academy

Title

Predictable & Precise Bone Regeneration with Autologous Dentinal Graft

Abstract

The recent popularity of implant dentistry has led to an increasing demand for alveolar bone regeneration. Autogenous bone grafting is still the gold standard for bone augmentation because of its excellent osteoinductivity and osteoconductivity, but it has some impediments such as limited availability, donor site morbidity, and also high resorption rates of up to 50%. 

Alternative graft materials including allografts, xenografts, and alloplastic bone grafts are clinically used, but they have disadvantages such as high cost and limited osteoinductivity. Among these, demineralized freeze-dried bone allografts (DFDBAs) have been widely used for alveolar bone augmentation because of their natural structure and inclusion of growth factors such as bone morphogenetic proteins (BMPs), ever since successful bone augmentation with DFDBAs in humans was first shown in 1981. However, DFDBA carries the risk of disease transmission. 

The structure and composition of dentin are similar to that of bone, consisting of collagen (20%), hydroxyapatite (70%), and body fluid (10%) in weight, so it is thought to have significant osteoconductivity. Furthermore, dentin matrix has some osteoinductivity because it contains BMPs. Thus, dentin or dentin matrix is expected to serve as a bone substitute. Mineralized Dentin Matrix (MDM) possesses excellent biocompatibility. Demineralized Dentin Matrix (DDM) is not only biocompatible but also osteoinductive, similar to demineralized bone matrix. Partial Demineralized Dentine Matrix (PDDM) possess all the properties of MDM & DDM.

We sometimes encounter cases that require the extraction of teeth prior to oral rehabilitation using dental implants. It is beneficial if we can utilize these extracted teeth, which are usually discarded, as autologous grafting material. Kim et al. applied both mineralized dentin and demineralized dentin matrix particles in dental implant surgery and reported successful bone regeneration.